The ineffectiveness of zymosan in altering the heterotransplantation of tumors to rats.
نویسندگان
چکیده
The successful transplantation and serial propa gation of heterologous tumors through successive generations of latoratory animals are sought for experimental purposes. Total-body irradiation of hosts, alone or in combination with cortisone in jections, is now being used to alter the natural immunity of hosts to foreign tissues (1, 10). The discovery by Pillemer that a normal serum euglobulin, properdin, has nonspecific bactericidal, virucidal, and hemolytic activities (4, 6) has sug gested that this globulin might play a role in host resistance to tumor transplantation. Ross and his associates demonstrated that the properdin titer falls to low levels following totalbody irradiation (8). Toolan has demonstrated that total-body irradiation reduces resistance to heterologous tumor transplantation (10). It seemed possible, therefore, that a reduction in properdin titer might aid heterologous tumor growth. Zymosan, the insoluble residue from yeast cells that have been digested with trypsin and ex tracted with water and alcohol, has been demon strated to cause marked reduction in serum properdin levels of laboratory animals (7). It was the purpose of this study to evaluate the effect of zymosan administration on trans plantation and serial propagation of heterologous tumors in rats.
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ورودعنوان ژورنال:
- Cancer research
دوره 18 3 شماره
صفحات -
تاریخ انتشار 1958